Naslov
Increase in CD23(+) B cells in infants with bronchiolitis is accompanied by appearance of IgE and IgG4 antibodies specific for respiratory syncytial virus
(Increase in CD23(+) B cells in infants with bronchiolitis is accompanied by appearance of ige and igg4 antibodies specific for respiratory syncytial virus)

Autori
Rabatić, Sabina ; Gagro, Alenka ; Lokar Kolbas, Renata ; Kršulović-Hrešić, Vilka ; Vrtar, Zvonimir ; Popow Kraupp, Therese ; Draženović, Vladimir ; Mlinarić-Galinović, Gordana

Izvornik
Journal of infectious diseases (0022-1899) 175 (1997), 1; 32-37

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human lymphocytes-b.; increased expression; allergic-asthma; responses

Sažetak
Infection with respiratory syncytial virus (RSV) may induce asthma-like symptoms and RSV-specific IgE in infected infants as a result of Th2-like response to RSV. The effect of RSV infection on the expression of B cell antigens CD21 and CD23, putative participants in Th2 responses, was investigated. Samples from bronchiolitic infants (n = 19) were tested by three-color immunofluorescence flow cytometry during the acute phase of infection and 4-6 weeks later. In 6 of 10 RSV-positive infants, the percentage of CD23(+) B cells was higher than in 9 RSV-negative children and in controls. Both CD21(+) and CD21(-) B cells exhibited a higher percentage of CD23. The group with increased expression of CD23 antigen had RSV-specific IgE and IgG4 antibodies. These findings corroborate the hypothesis that RSV could provoke a Th2-type response, but the relationship between CD23 antigen and RSV infection must be determined.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA