Naslov
Specific spectroscopic MR metabolite profile and tau proteins profile in autopsy-proven Creutzfeldt-Jakob's disease in a patient with non-specific initial EEG, MRI and negative 14-3-3 protein

Autori
Šarac, Helena ; Hajnšek, Sanja ; Bašić, Silvio ; Henigsberg, Neven ; Radoš, Marko ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Neurology / - Brisel : EFNS, 2007, 58-58

Skup
11th Congress of the European Federation of Neurological Societies (EFNS)

Mjesto i datum
Bruxelles, Belgija, 25.08.2007. - 28.08.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sporadic Creutzfeldt-Jakob disease; magnetic resonance spectroscopy; tau proteins; cerebrospinal fluid

Sažetak
Over the last several years, it has became clear that electroencephalogram (EEG), magnetic resonance imaging (MRI) and measurement of cerebrospinal fluid (CSF) 14-3-3 proteins are of limited potential in the clinical diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD). However, some recent reports suggested that magnetic resonance spectroscopy (MRS) and measurement of CSF total tau (t-tau) and phospho-tau (p-tau) proteins could be more useful for ante mortem diagnosis of sCJD. We therefore included these two methods in the diagnostic procedure of a patient with clinically suspected (and later autopsy-proven) sCJD. In contrast to non-specific EEG and MRI findings and negative 14-3-3 proteins in CSF, MRS revealed metabolic alterations in regions of the brain that looked apparently normal on MRI, while tau proteins profiles showed increased levels of both non-phosphorylated and some phosphorylated tau isoforms. We concluded that a combination of serial functional MRI together with MRS and measurement of CSF tau proteins in patients with rapidly progressive dementia syndrome helps to obtain a more reliable early diagnosis of sCJD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA