Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status

Marušić Vrsalović, Maruška; Pejša, Vlatko; Štoos-Veić, Tajana; Ostojić Kolonić, Slobodanka; Ajduković, Radmila; Hariš, Višnja; Jakšić, Ozren; Kušec, Rajko

doi:10.4161/cbt.6.9.4568

Pregled bibliografske jedinice broj: 322821

Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status

Marušić Vrsalović, Maruška; Pejša, Vlatko; Štoos-Veić, Tajana; Ostojić Kolonić, Slobodanka; Ajduković, Radmila; Hariš, Višnja; Jakšić, Ozren; Kušec, Rajko

Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status // Cancer biology & therapy, 6 (2007), 9; 1430-1432 doi:10.4161/cbt.6.9.4568 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 322821 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone marrow renin-angiotensin system expression in polycythemia vera and essential thrombocythemia depends on JAK2 mutational status

Autori
Marušić Vrsalović, Maruška ; Pejša, Vlatko ; Štoos-Veić, Tajana ; Ostojić Kolonić, Slobodanka ; Ajduković, Radmila ; Hariš, Višnja ; Jakšić, Ozren ; Kušec, Rajko

Izvornik
Cancer biology & therapy (1538-4047) 6 (2007), 9; 1430-1432

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone marrow renin-angiotensin system; polycythemia vera; essential thrombocythemia; JAK2

Sažetak
Recent observations raise possibility for constitutively active, mutated JAK2 to modulate expression of RAS genes in CMPD. We analyzed the expression of AGT, renin, AT2R1 and ACE genes in normal and bone marrows of PV and ET patients with the respect to the presence of V617F JAK2 mutation. PV and ET had different expression patterns of major RAS components compared to normal BM which was primarily associated with the JAK2V617F mutation and less with PV or ET disease phenotype. However, AT2R1 was exclusively markedly upregulated only in PV, while ET showed moderate expression irrespective of the JAK2 mutational status.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

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