Naslov
No adverse effect of ABVD chemotherapy in a patient with chronic hepatitis C and Hodgkin's disease.

Autori
Pejša, Vlatko ; Grgurević, Ivica ; Kujundžić, Milan ; Martinović, Marko ; Stančić, Vladimir ; Donley, Kyle ; Pavletic, Steven

Izvornik
Wiener Klinische Wochenschrift (0043-5325) 116 (2004), 19-20; 695-697

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, case reports, stručni

Ključne riječi
AABVD chemotherapy; chronic hepatitis C; Hodgkin's disease
(ABVD chemotherapy; chronic hepatitis C; Hodgkin's disease.)

Sažetak
There is insufficient information on the effects of chemotherapy protocols for Hodgkin's disease (HD) and the course of coexisting hepatitis C virus (HCV) infection. A single literature case reported a patient with HD who developed fulminant hepatitis and hepatic coma after receiving chemotherapy. The case described here is of a female patient previously exposed to prolonged war stress, complicated by intravenous drug abuse and chronic hepatitis C. One year after diagnosis of HCV infection she was diagnosed with HD (nodular sclerosis type II, clinical stage IIIB). The patient received six cycles of ABVD chemotherapy (doxorubicin, bleomycin, vinblastine and dacarbazine) resulting in complete remission of HD. There was no hepatitis flare either during or after chemotherapy. In conclusion, there were no adverse effects of the ABVD regimen on the course of HCV infection in this patient who was successfully treated for HD. Because concurrent HCV infection and HD is extremely rare, we discuss here the possibility of the synergistic contribution of chronic war stress and hepatitis C infection in the pathogenesis of HD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA