Naslov
Analysis of IL-6-174 promotor polymorphism in GEP-NET

Autori
Berković, Maja ; Jokić, Mladen ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th Annual ENETS conference "Diagnosis and treatment of neuroendocrine tumor disease" : abstracts / - , 2006

Skup
Annual ENETS conference (3 ; 2006)

Mjesto i datum
Prag, Češka Republika, 22.03.2006. - 24.03.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
GEP-NET; IL-6 promotor polymorphism; tumor susceptibility

Sažetak
GEP-NETs produce biogenic amines, especially CgA. It has been shown that CgA levels correlate with TNF-alpha suggesting a link between neuroendocrine and immune system. TNF-alpha stimulates IL-6 production in certain tumor cells. The aim was to investigate wheather the presence of G allele in the IL-6-174 polymorphism predisposes to GEP-NET or carries a poor outcome. 53 GEP-NET patients and 139 unrelated healthy volunteers were genotyped for the -174 IL-6 promotor polymorphism using PCR-NlaIII RFLP. There was no statistically significant difference in the frequency of the G allele associated with GEP-NET development.

Izvorni jezik
Engleski

POVEZANOST RADA