Naslov
Time-dependent diuretic response in rats treated with juniper berry preparations

Autori
Stanić, Gordana ; Samaržija, Ita ; Blažević, Nikola

Izvornik
PTR. Phytotherapy research (0951-418X) 12 (1998), 7; 494-497

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Juniperus communis L.; juniper berry; essential oil; infusion; terpinen-4-ol; diuretic activity

Sažetak
The infusion and the essential oil of juniper berries (Juniperus communis L.) as well as terpinen-4-ol were tested for diuresis response in rats. GC analysis of the oil obtained from the drug sample revealed that the ratio between the pinene fraction and terpinene-4-ol was 5:1. In a 1 day experiment the effect of diuresis reduction was observed and compared with the effect of vasopessin (ADH). The effect of the smalest dose of ADH (0.004 IU/100 g b.w.) intraperitoneally administered was comparable to the effect of a 10% drug infusion and 0.1% essential oil solution, while the effect of 0.4 IU/100g b.w. of ADH was comparable to that of a 0.01% solution of terpinen-4-ol. During a 3 day experiment diuresis was stimulated after the second application and espacially after the third application of test solutions. Among tested preaprations a 10% drug infusion excreted the most considerable diuretic activity. After 72 h, i.e. three oral doses of 5 ml/100 g b.w. of drug infusion, the cumulative urine volume was 44% above the control value. The results suggest that the diuretic activity of juniper berries cannot be attributed only to the essential oil but also to hydrophilic drug constituents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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