Naslov
Cytogenetic Abnormalities in Acute Leukemia and Myelodysplasia

Autori
Hitrec, Vlasta ; Labar, Boris ; Nemet, Damir ; Jakšić, Branimir ; Susterčić, Dunja ; Kardum, Ika ; Begović, Davor ; Mršić, Sanja

Izvornik
Croatian medical journal (0353-9504) 34 (1993), 3; 220-229

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute lymphoblastic leukemia ; acute myeloid leukemia ; chromosomal abnormalities ; chromosomal translocation ; cytogenetics ; myelodysplastie syndrome

Sažetak
Aim. To evaluate the type and incidence of chromosomal abnormalities in 271 patients with acute leukemia and 71 patients with myelodysplasia. Methods. Banded chromosome analyses were performed on direct, 24- or 48-hour cultured and, in some cases, synchronized preparations of fresh bone marrow samples. Chromosome abnormalities were designated using the International System for Human Cytogenetic Nomenclature (ISCN, 1985). Results. Clonal chromosomal abnormalities were found in 119 (64%) patients with acute myelogenous leukemia. Fifty (75%) patients with acute lymphoblastic leukemia had clonal chromosomal abnormalities, half of which translocations. Clonal chromosomal abnormalities were found in 13 (57%) patients with acute unclassified leukemia and in 39 (55%) patients with myelodysplastic syndrome. Monosomies and deletions were predominantly revealed. Conclusions. Chromosomal abnormalities were found in 65% of patients with acute leukemia and in 55% with myelodysplasia. Most of them highly correlated with the specific F AB subtype of acute leukemia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA