Naslov
Stress syndrome: Ryanodine receptor (RYR1) gene in malignant hyperthermia in humans and pigs

Autori
Bašić Ivan, Tadić Zoran, Lacković Vesna, Gomerčić Ana

Izvornik
Periodicum biologorum (0031-5362) 99 (1997), 3; 313-317

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
malignant hyperthermia; stress syndrome; RYR1 gene; DNA testing; halothane testing

Sažetak
Anesthesia can induce skeletal muscle rigidity, hypermetabolism and high fever in men genetically predisposed to malignant hyperthermia ; such episodes can lead to tissue damage and sudden death, if not immediately reversed. In pigs with reciprocal condition stress can induce death or lead to devalued meat production. Muscle contraction is controlled by sarcoplasmatic Ca 2+, and the abnormalities mention above can reside in the skeletal muscle Ca2+ release channel geneRYR1. It has been reported that single RYR1 mutation causes malignant hyperthermia in all breeds of pigs and in some human families. The substitution of Cis for Arg 615 has been found to be the cause of malignant hyperthermia in all breeds of swine: the appearance of the corresponding mutation, Cys for Arg 615 in few human families also co segregate with malignant hyperthermia. However, linkage of malignant hyperthermia to RYR1 gene is not observed in all human families with malignant hyperthermia. The results described in a this paper present the prevalence of the porcine stress syndrome mutation in breeds of pigs in Croatia, as well as the influence of malignant hyperthermia genotype on meat quality of pigs.

Izvorni jezik
Engleski

POVEZANOST RADA