Pregled bibliografske jedinice broj: 32194
Association between deletion polymorphism of the angiotensin converting enzyme and corticosteroid therapy
Association between deletion polymorphism of the angiotensin converting enzyme and corticosteroid therapy // Clinical Chemistry and Laboratory Medicine
Firenca, Italija, 1999. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 32194 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Association between deletion polymorphism of the angiotensin converting enzyme and corticosteroid therapy
Autori
Bosnić, Dubravka ; Sertić, Jadranka ; Sentić, M. ; Anić, B. ; Čvorišćec, Dubravka ; Čikeš, Nada ; Stavljenić-Rukavina, Ana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Clinical Chemistry and Laboratory Medicine
/ - , 1999
Skup
17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine 1st International Congress of Clinical Molecular Biology (CMB)
Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
ACE gene; corticosteroids
Sažetak
Polymorphism in the gene for angiotensin converting enzyme (ACE), especially the DD genotype as a genetic candidate for atherosclerosis, has been implicated in the pathogenesis of a variety of cardiovascular disorders, hypertension, diabetic and IgA nephropathy, carotid artery thickening, and lacunar cerebral stroke. Systemic lupus erythematosus (SLE) is a multifactorial disease characterized by renal dysfunction, arthritis, and CNS involvement. We examined ACE polymorphism, as a possible marker in glomerulosclerosis leading to loss of kidney function in 50 SLE patients with kidney involvement, treated with corticosteroid therapy. The deletion/insertion (I/D) screening of intron 16 of the ACE gene was performed by polymerase chain reaction. The DD, ID and II genotypes were found in 60%, 24%, and 11% of patients, compared with 24%, 52%, 24% in the control group respectively. The results also show different response to the corticosterid treatment depending on the ACE genotypes studied. The percentages of patients with DD, ID and II genotype who had good response to treatment are 66.7%, 75%, 62, 5%, respectively, while 33.3%, 25% and 37.5% patients had a bad course and poor response to treatment. The findings suggest firstly that SLE are partially determined by genetic disposition. and secondly increased proportion of ACE ID genotype with good response to corticosteroids therapy might be of prognostic significance, predicting therapeutic efficiency. The molecular mechanisms involved in these response differences need to be investigated in further studies.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
