Naslov
Potentiometric determination of N-acetylcysteine based on its reduction action on Fe(III)

Autori
Komljenović, Josipa ; Radić, Njegomir

Izvornik
Acta Pharmaceutica (1330-0075) 43 (1993); 99-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-acetylcysteine; potentiometric method; fluoride ion-selective electrode

Sažetak
A simple potentiometric method for the determination of N-acetylcysteine (NAC) is based on its reduction action on Fe(III) in acidic fluoride solution, pH 2. The method is described as an equilibrium method and kinetic method. The recorded potential value of the cell with fluoride ion-selective electrode or the calculated average rate are found to be linear with NAC concentration in solution. Good linearity is achieved in the range of NAC concentration from 2.0 x 10-4 mol dm-3 to 1.5 x 10-3 mol dm-3 . The kinetic method is proposed as the procedure of choice for the determination of NAC in pure substances or in pharmaceutical formulations, with relative standard deviation from 0.51 to 2.17 %.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA