Naslov
Virulence of different Legionella species in A/J mice.

Autori
Gobin, Ivana ; Šantić, Marina ; Selenić, Kaća ; Šarec, Martina ; Abu Kwaik, Yousef ; Dorić, Miljenko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book / - , 2007

Skup
Power of microbes in industry and environment

Mjesto i datum
Zadar, Hrvatska, 2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
legionella; animal model; lungs

Sažetak
Legionellae are environmental organisms that can cause disease in humans. The clinical manifestation of legionella infection range from the flu like symptoms to potentally fatal pneumonia and multisystem disease. Legionella pneumophila is the predominant cause of Legionnaires’ disease in the United States and Europe in contrast to L. longbeachae which is the leading cause of the legionelosis in Australia. L. micdadei cause disease in immunocompromised people while L. steigerwaltii is not pathogen to humans. To determine the differences in virulence of those four legionella strains, A/J mice were intratracheally inoculated. At different time points after infection (2, 24, 48 and 72 hours) mice were sacrificed, and the lungs were removed and proceed for determination of cfu (colony forming units). Our results showed the dramatic difference in mortality rate in A/J mice between those four strains. For L. longbeachae LD 50 was 104 cfu in comparison to L. pnemophila infection with LD 50 of 108 cfu. For L. micdadei LD 50 was 108 cfu while all mice infected with L. steigerwaltii survived infection. We conclude that L. longbeachae serogroup 1 causes a more severe infection in A/J mice compared to other legionella strains.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA