Naslov
Apolipoprotein E in myasthenia gravis

Autori
Šoštarko, Marija ; Sertić, Jadranka ; Gregurić, Nevenka ; Stavljenić-Rukavina, Ana ; Brzović, Zdravko ; Matić, V.

Izvornik
Annals of the New York Academy of Sciences (0077-8923) 841 (1998); 592-595

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
apo E ; myasthenia gravis

Sažetak
It is believed that apo E may moderate T lymphocytes by activation of mitogens or antigens. In that way, it has an influence on immune processes and it is reasonable to study the relationship between apo E genotypes and myasthenia gravis phenotypes. We tried to find any feature connected to the development of a different intensity of myasthenia gravis. The obtained results show that 46.43% of the observed patients have apo E2/4 genotype ; in this group, most patients, namely 18 patients or 32.14%, have the severe form of myasthenia gravis and there is no patient with the mild form of myasthenia gravis. Ten patients or 17.86% with the mild form of myasthenia gravis have apo E3/3 genotype. Otherwise, apo E3/3 genotype is the most numerous in the healthy population. The obtained results show a significant difference between the intensity of myasthenia gravis patients' signs and symptoms and their apo E genotypes. The anti-AChR antibody titers show a positive correlation with the intensity of clinical signs and symptoms of myasthenia gravis. The obtained results may add to the possibility that apolipoprotein E, especially with genotype apo E2/4, might influence of the immune response in myasthenia gravis patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA