Naslov
Chromosomal Aberration and Chromosome Y Microdeletion of IVF-ICSI Male Patients

Autori
Vlastelić, Ivan ; Buretić-Tomljanović, Alena ; Kapović, Miljenko ; Randić, Ljiljana ; Tramišak-Milaković, Tamara ; Ljiljak, Dejan ; Radojčić Badovinac, Anđelka

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

ISBN
88-7587-152-3

Skup
13th World Congress on In Vitro Fertilization, Assisted Reproduction and Genetics

Mjesto i datum
Istanbul, Turska, 26.05.2005. - 29.05.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
male infertility; chromosomal aberrations; Y chromosome microdeletions

Sažetak
Chromosomal aberrations disturb gamete formation and impair male fertility. The frequency of chromosomal abnormalities in infertile males ranges between 12, 6% and 17, 6%. Since male infertility is largely due to impairment of gametogenesis, in which a number of genes participate, mutations in spermatogenic genes would also result in impaired spermatogenesis, leading to infertility. Recombinant DNA techniques provide the potential for explaining as much as 10% of idiopathic forms of infertility. Deletions in AZF region can cause severe spermatogenic defects ranging from non-obstructive azoospermia to oligozoospermia. The use of intracytoplasmatic sperm injection technique (ICSI) allows AZF deletions to be passed to male offspring. Out of 78 cases examined, 21 had some chromosomal abnormality (26, 9%), while Y-chromosomal microdeletions were found in two of them (2, 56%).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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