Naslov
Kinetic potentiometric determination of some thiols with iodide ion-sensitive electrode

Autori
Radić, Njegomir ; Martinović, Anita

Izvornik
Analytical Letters (0003-2719) 40 (2007), 15; 2851-2859

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
D-penicillamine; iodide ion selective electrode; kinetic potentiometry; L-cysteine; N-acetyl-L-cysteine; L-glutathione; thiols

Sažetak
This paper describes a kinetic potentiometric method for the determination of thiols (RSH): l-cysteine (cys), N-acetyl-l-cysteine (NAC), l-glutathione (glu), and d-penicillamine (pen). The proposed method is based on the reaction of formation the sparingly soluble salts, RSAg, between RSH and Ag+ ions. During this reaction potential-time curves were recorded by using an electrochemical cell with commercial iodide selective electrode. The rectilinear calibration graphs are obtained in the RSH concentration range from 1.0×10-5 to 1.0×10-3 M. The applicability of the proposed method was demonstrated by determination of chosen compounds in pharmaceutical dosage forms.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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