Pregled bibliografske jedinice broj: 317858
Statistical analysis of DNA microarray data: Limitations and perspectives
Statistical analysis of DNA microarray data: Limitations and perspectives // Program & Book of Abstracts MMC 2007 / Ante Graovac, Biserka Pokrić (ur.).
Zagreb: Institut Ruđer Bošković, 2007. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 317858 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Statistical analysis of DNA microarray data: Limitations and perspectives
Autori
Konjevoda, Paško ; Štambuk, Nikola ; Pokrić, Biserka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Program & Book of Abstracts MMC 2007
/ Ante Graovac, Biserka Pokrić - Zagreb : Institut Ruđer Bošković, 2007
ISBN
978-953-6690-70-1
Skup
MMC 2007 – Mathematical Methods in Chemistry 2007
Mjesto i datum
Split, Hrvatska, 22.09.2007. - 24.09.2007
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
DNA; microarray; gene; statistics; analysis
Sažetak
DNA microarray analysis is a laboratory technique that permits simultaneous measurement of messenger RNA expression for larger number of genes. The original motivation behind development of this technology was automated discovery of gene networks. However, statistical basis of DNA microarray data analysis is still controversial. The most important statistical problems are: normalization methods, a huge number of genes (variables) versus a small number of observations (the dimensionality of the data), multiple comparison and low power. In our paper we explain how statistical limitations prevented DNA microarray to fulfil its original role.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982929-2524 - Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka (Štambuk, Nikola, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
