Naslov
Sedative and anticonvulsant effects of zolpidem in adult and aged mice

Autori
Peričić, Danka ; Vlainić Lazić, Josipa ; Švob Štrac Dubravka

Izvornik
Journal of neural transmission (0300-9564) 115 (2008), 6; 795-802

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
zolpidem ; aging ; seizure threshold ; picrotoxin ; pentylenetetrazole ; locomotor activity

Sažetak
To evaluate possible age-related differences in the behavioural effects of zolpidem, a widely used hypnotic, we compared the effects of zolpidem on the locomotor activity and on the seizure threshold for pentylenetetrazole (PTZ) and picrotoxin (given by i.v. infusion) between adult (3 months) and aged (13 months) mice. Zolpidem (10 mg/kg) produced similar enhancements of the seizure threshold in adult and aged mice. The drug was more potent against PTZ- than against picrotoxin-induced seizures. Diazepam (1 mg/kg), which was taken for comparison, had a weaker effect on picrotoxin-induced tonic seizures in aged than in adult mice. Sedative effect of zolpidem (10 mg/kg), as assessed by its effect on the locomotor activity, was very strong in both groups of mice. The results suggest that sedative and antiseizure effects of zolpidem are not changed in aged mice.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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