Naslov
The Comparison of the Qualitative Dermatoglyphics Analysis and Genetic Markers in Different Types of Lung Carcinoma

Autori
Pavićević, Radomir ; Miličić, Jasna ; Pavićević, Lukrecija ; Bubanović, Gordana ; Peričić, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CHI Human Genome Project Europe / --- - : Cambridge Healthtech Institute (CHI), 1997, 163-163

Skup
CHI Human Genome Project Europe

Mjesto i datum
Monako, 19.05.1997. - 21.05.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
anthropology; population genetics; qualitative dermatogliphic traits; different types of carcinoma

Sažetak
Qualitative dermatoglyphic traits (whorls, loops and arches) on fingers and palms are studied in four different types of bronchopulmonary carcinomas in males: the non small cell lung cancer 185 (NSCLC) and 31 patients with small cell lung cancer (SCLC). Hiernaux Dg biological distance shows three separate clusters - first patients with carcinoma microcellulare, second patients with carcinoma planocellulare and third patients with adenocarcinoma and carcinoma macrocellulare. The aim of the study is to compare the differences found in dermatoglyphic analysis and the results of measurements of serum and tissue tumor markers in different types of lung cancer from our preliminary research and described in literature within the past few years. An increasing influence upon the clinical decisions about initial treatment and in clinical stage determination is the level of NSE (neuron specific enolase) antigen and myc oncogene mutations in SCLC, similarly in NSCLC most prolific markers are CYFRA21-1 (cytokeratin -19 fragment antigen), TPA (tissue polypeptide antigen) and CEA (carcinoembryonic antigen), ras oncogene and p53 tumor suppressor gene mutations. SQCC-a (squamous cell carcinoma antigen) is tumor markers for squamous cell carcinoma, while ras oncogene mutations are most frequently found in adenocarcinoma and for large cell carcinoma. Therefore, as dermatoglyphic analysis shows, carcinomas are as a dermatoglyphs polygenetically determined, and genetic factors are suspected to have an important role in the occurrence of small cell carcinoma (SCLC), as well as in other types of non small cell carcinoma (NSCLC). Their influence can also be traced through the difference expressed on the genetical level of changes, detected by genetic markers.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija

POVEZANOST RADA