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Pregled bibliografske jedinice broj: 314832

The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer

Bobinac, Dragica; Marić, Ivana; Markić, Dean; Cvijanović, Olga; Španjol, Josip; Ćelić, Tanja; Fučkar, Željko
The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer // Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto (ur.).
New York (NY): Springer, 2007. str. s61-s61 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 314832 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer

Autori
Bobinac, Dragica ; Marić, Ivana ; Markić, Dean ; Cvijanović, Olga ; Španjol, Josip ; Ćelić, Tanja ; Fučkar, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto - New York (NY) : Springer, 2007, S61-s61

Skup
European Symposium on Calcified Tissues (34 ; 2007)

Mjesto i datum
Kopenhagen, Danska, 05.05.2007. - 09.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
bone morphogenetic protein-7; BMP-receptors; kidney; kidney cancer; immunohistochemistry

Sažetak
Bone morphogenetic protein-7 has an important role during fetal kidney development. In adult human kidney the expression was found in proximal tubule and glomerular podocytes. The function of BMP-7 in normal kidney is still unclear but the reviews revealed protective role of BMP-7 in acute and chronic kidney disease. BMP-7 is efficient as antifibrotic factor and is able to reverse epithelial-mesenchymal transformation. The aim of the study was to explore the expression of BMP-7 in human normal kidney and kidney cancer cells. Immunohistochemical staining with anti BMP-7, anti BMPR-IA, anti BMPR-IB and anti BMPR-II was performed. Slides were incubated with the primary antibodies overnight at 4°C in PBS. The expression of BMP-7 was found in epithelial cells of distal tubule. But the expression of related BMPs receptors was found in epithelial cells od fistal and proximal tubules. Among receptors BMPR-IB expression was very strong. In the tissue of kidney cancer the expression of BMP-7 was negative. In the borderline tissue of the kidney cancer the expression of BMP-7 was still present. In the kidney cancer cells the expression of BMPs receptors was present especially BMPR-IA and BMPR-IB while BMPR-II was less expressed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Bobinac, Dragica, MZOS ) ( CroRIS)
062-0620226-0208 - Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva (Crnčević Orlić, Željka, MZOS ) ( CroRIS)
062-0620226-0209 - Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva (Marić, Ivana, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Josip Španjol (autor)

Avatar Url Željko Fučkar (autor)

Avatar Url Ivana Marić (autor)

Avatar Url Dragica Bobinac (autor)

Avatar Url Olga Cvijanović Peloza (autor)

Avatar Url Tanja Ćelić (autor)

Avatar Url Dean Markić (autor)

Citiraj ovu publikaciju:

Bobinac, Dragica; Marić, Ivana; Markić, Dean; Cvijanović, Olga; Španjol, Josip; Ćelić, Tanja; Fučkar, Željko
The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer // Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S) / Civitelli, Roberto (ur.).
New York (NY): Springer, 2007. str. s61-s61 (poster, međunarodna recenzija, sažetak, znanstveni)
Bobinac, D., Marić, I., Markić, D., Cvijanović, O., Španjol, J., Ćelić, T. & Fučkar, Ž. (2007) The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer. U: Civitelli, R. (ur.)Abstracts of the 34th European Symposium on Calcified Tissues ; u: Calcified Tissue International (2007) (S).
@article{article, author = {Bobinac, Dragica and Mari\'{c}, Ivana and Marki\'{c}, Dean and Cvijanovi\'{c}, Olga and \v{S}panjol, Josip and \'{C}eli\'{c}, Tanja and Fu\v{c}kar, \v{Z}eljko}, editor = {Civitelli, R.}, year = {2007}, pages = {s61-s61}, keywords = {bone morphogenetic protein-7, BMP-receptors, kidney, kidney cancer, immunohistochemistry}, title = {The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer}, keyword = {bone morphogenetic protein-7, BMP-receptors, kidney, kidney cancer, immunohistochemistry}, publisher = {Springer}, publisherplace = {Kopenhagen, Danska} }
@article{article, author = {Bobinac, Dragica and Mari\'{c}, Ivana and Marki\'{c}, Dean and Cvijanovi\'{c}, Olga and \v{S}panjol, Josip and \'{C}eli\'{c}, Tanja and Fu\v{c}kar, \v{Z}eljko}, editor = {Civitelli, R.}, year = {2007}, pages = {s61-s61}, keywords = {bone morphogenetic protein-7, BMP-receptors, kidney, kidney cancer, immunohistochemistry}, title = {The expression of bone morphogenetic protein-7 and its receptors in the human normal kidney and kidney cancer}, keyword = {bone morphogenetic protein-7, BMP-receptors, kidney, kidney cancer, immunohistochemistry}, publisher = {Springer}, publisherplace = {Kopenhagen, Danska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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