Naslov
Experiments of Nature: do they still point the way?

Autori
Buneta, Drago ; Jakšić, Mirjana ; Sabioncello, Ante ; Tješić-Drinković, D

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum biologorum, 99 (Suppl 2) / - , 1997, 16-16

Skup
1997 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Zagreb, Hrvatska, 06.11.1977. - 07.11.1977

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
BCG infection; mucocutaneous candidiasis; Mantoux test; immunophenotyping; immunoglobulin level

Sažetak
Experiments of Nature, a term which denotes inborn errors of metabolism and/or somatic cell (e.g. lymphocytes) dysfunction, have long been a driving force in scientific achievements of contemporary medicine. To illustrate this we are presenting two children with such a disorder: a boy of 20 months, with disseminated BCG infection, and a 7 year old girl who, besides chronic mucocutaneous candidiasis, suffered from a persistent BCG infection, localized primarily at the site of vaccination. DTH reaction (PPD 3 TU, 10 TU) was negative in both patients, despite findings of acid-fast bacille in the granulomatous tissue of the skin, lymph node tissue, and bronchial aspirate. Immunologic studies in the boy showed normal to borderline lymphocyte count (30% in differential, 3600 cells per microliter) and CD3 count (47%, 1704 cells per microliter), low CD4 count (40%, 680 cells per microliter), and CD8 count (16%, 272 cells per microliter), normal CD4/CD8 ratio (2.5), and normal mitotic activity (PHA 93586 Cpm), normal leukocyte number (12100 cells per microliter), and NBT test (30% positive), normal serum immunoglobulin levels (IgG 8.51, IgA 0.70 and IgM 1.48 g/L), and normal issoagglutinin titer (anti-B positive 1:256). Findings in the girl, which have been obtained, were similar to the respective findings in the boy. As cases of SCID, CGD, CD4 deficiency and IFN-gamma receptor deficiency have been described in some children with disseminated BCG infection it could be said that, despite the most recent achievements in mollecular biological techniques, Experiments of Nature still point the way, just as AE Garrod and RA Good wrote long time ago.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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