Alterations of FHIT and P53 genes in keratocystic odontogentic tumor, dentigerous and radicular cyst

Malčić, Ana; Jukić, Silvana; Anić, Ivica; Pavelić, Božidar; Kapitanović, Sanja; Krušlin, Božo; Pavelić, Krešimir

doi:10.1111/j.1600-0714.2007.00622.x

Pregled bibliografske jedinice broj: 314049

Alterations of FHIT and P53 genes in keratocystic odontogentic tumor, dentigerous and radicular cyst

Malčić, Ana; Jukić, Silvana; Anić, Ivica; Pavelić, Božidar; Kapitanović, Sanja; Krušlin, Božo; Pavelić, Krešimir

Alterations of FHIT and P53 genes in keratocystic odontogentic tumor, dentigerous and radicular cyst // Journal of oral pathology & medicine, 37 (2008), 5; 294-301 doi:10.1111/j.1600-0714.2007.00622.x (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 314049 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Alterations of FHIT and P53 genes in keratocystic odontogentic tumor, dentigerous and radicular cyst

Autori
Malčić, Ana ; Jukić, Silvana ; Anić, Ivica ; Pavelić, Božidar ; Kapitanović, Sanja ; Krušlin, Božo ; Pavelić, Krešimir

Izvornik
Journal of oral pathology & medicine (0904-2512) 37 (2008), 5; 294-301

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
FHIT ; keratocystic odontogenic tumor ; odontogenic cyst ; P53

Sažetak
The purpose of this study was to determine fragile histidine triad (FHIT)and p53 protein expression, and to analyze FHIT and p53 gene status in keratocystic odontogenic tumor(KOT), dentigerous cysts (DC) and radicular cysts (RC). The methods used were immunohisto chemistry and molecular genetic methods including loss of heterozygosity (LOH)and gene sequencing. FHIT protein expression was different among groups. Aberrant expression was the highest in KOT, then in RC and DC. p53 protein expression was different among groups. LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT andp 53 respectively. Mutation of p53 gene at codon 237 was observed in only two specimens(one KOT and one DC). Of the six frozen specimens, three exhibited FHIT gene LOH(two RC and one KOT). KOT showed loss of exons 6– 7 at FHIT locus and mutation at codon 237 at 1qa p53 locus, ¸but this could be a chance result. Aberrations of FHIT and p53 genes/ proteins could be considered markers responsible for the development of odontogenic lesions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Dentalna medicina

POVEZANOST RADA

Projekti:
MZOS-065-0650444-0418 - Eksperimentalna i klinička endodontologija (Anić, Ivica, MZOS ) ( CroRIS)
MZOS-065-0650445-0434 - Epidemiološki aspekti endodoncije u Republici Hrvatskoj (Krmek, Silvana, MZOS ) ( CroRIS)
MZOS-098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
MZOS-108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( CroRIS)
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti