Naslov
Escherichia coli virulence factors in chronic bacterial prostatitis

Autori
Vraneš, Jasmina ; Antolović-Požgain, Arlen ; Šenjug, Marko ; Bedenić, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 17th European Congress of Clinical Microbiology and Infectious Diseases : 17th ECCMID and 25th International Congress of Chemotherapy : 25th ICC / - , 2007, 820-820

Skup
European Congress of Clinical Microbiology and Infectious Diseases (17 ; 2007)

Mjesto i datum
München, Njemačka,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Escherichia coli; virulence; prostatitis

Sažetak
Urinary tract infection (UTI) is the principal extraintestinal syndrome caused by Escherichia coli. Although most common among women, it is also significant problem among men, who can experience cystitis, pyelonephritis and prostatitis. Better enderstanding of the pathogenesis of UTI and prostatitis in men is necessary to guide the development of effective preventive measures. The aim of this study was to determine the prevalence of various virulence factors among E. coli strains causing chronic prostatitis (CPR, n = 25) and compare them with the strains isolated in acute (AP, n = 23) and chronic pyelonephritis (CP, n = 22), acute cystitis (AC, n = 22), and asymptomatic bacteriuria (ABU, n = 18). Total of 110 E. coli strains were isolated from 110 patients who presented with one of five clinical syndromes. Bacterial susceptibility to serum killing was measured by assessing bacterial regrowth after incubation in normal human serum.The expression of adhesins was defined by hemagglutination and inhibition of hemagglutination in microtiter plates. Serotyping was performed on glass slides and the production of hemolysin was tested on human blood agar plates. The most virulent strains were isolated from patients with AP, followed by strains isolated from patients with CPR. Strains isolated from patients with CPR were significantly more often resistant to the bactericidal activity of serum (BAS), significantly more often produced hemolysin and significantly more often expressed adhesins (p<0, 01) than did ABU and CP strains. P-fimbriated strains were most commonly detected in the AP and CPR groups, although AP strains expressed P-fimbriae significantly more often than did CPR strains (p<0, 05). CPR and AP groups of strains were significantly more often resistant to BAS than strains isolated in other diagnostic groups (p<0.01). There were significant correlations between resistance of E.coli strains to BAS and expression of mannose-resistant adhesins (C= 0, 365). The difference in antigenic structure did not influence on serum sensitivity of the strains. Conclusion: E. coli virulence factors such as adhesins, hemolysin and serum resistance may have important roles in the pathogenesis of chronic prostatitis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
International Journal of Antimicrobial Agents 29 (2007) (S1) S207, P821 ; doi: 10.1016/S0924-8579(07)70662-3

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