Naslov
Immune functions in children with malignant embryonal tumors

Autori
Sabioncello, Ante ; Rabatić, Sabina ; Svoboda-Beusan, Ivna ; Mažuran, Renata ; Crnojević-Ivanušić, Ružana ; Jovančević, Milivoj ; Batinica, Stipe ; Dekaris, Dragan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Periodicum biologorum, 92 / - , 1990, 150-151

Skup
2. kongres imunologa Jugoslavije

Mjesto i datum
Vrnjačka Banja, Jugoslavija, 29.05.1989. - 02.06.1989

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
neuroblastoma; nephroblastoma; Ewing's sarcoma; rhabdomyosarcoma; mesonephroma; lymphocyte subpopulations; flow cytometry; blast transformation; migration inhibition; NK activity; phagocyte functions

Sažetak
The aim was to investigate some of the parameters of systemic cellular immune reactions in children suffering with malignant embrional tumors. The blood was collected before surgery or after cytostatic and/or radiotherapy at the time when the leucocyte count reached at least 3x10^9/L. The lower percentages of T, Th and B lymphocytes and no reactivity to PPD in the migration inhibition test were found. The NK activity and phagocytic functions were impaired. Patients without metastases had loweer ADCC than both control and patients with metastases. Proliferative capacity of lymphocytes was increased and more pronounced in patients with metastases. Analysis of prognostic meanings of our findings needs additional testing.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA