Naslov
Detection of circulating immune complexes by the combined use of four methods

Autori
Sabioncello, Ante ; Mažuran, Renata ; Jušić, Dubravka ; Dekaris, Dragan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of the 1st Congress of Yugoslav Immunologists / Periodicum biologorum, 88(Supp 1) / - Zagreb : Hrvatsko prirodoslovno društvo, 1986, 273-274

Skup
First Congress of the Yugoslavian Immunology Society

Mjesto i datum
Opatija, Jugoslavija, 21.10.1985. - 25.10.1985

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
PEG precipitation ; Raji cell assay ; imgration inhibition test ; phagocytosis inhibition test

Sažetak
Immune complexes differ in physicochemical and biological properties. None of the numerous methods employed can detect all different circulating immune complexes. Therefore, a parallel use of a battery of tests, based on various principles, is proposed. We used four methods: polyethylene glycol precipitation based on physicochemical property, Raji cell assay based on the complement binding property, migration inhibition test and phagocytosis inhibition test based on the Fc- receptor binding property to test immune complexes in the sera of rheumatoid arthritis, ankylosing spondylitis and and different other diseases (psoriatic arthritis, systemic lupus erythematosus, myocharditis), as well as healthy controls. Our aim was to establish whether this combination of tests could successfully detect the presence of circulating immune complexes, and whether one of the tests would prove more suitable than the others for a given disease. Although there was no cerrelation between the results obtained by any two of the tests, we found a significant association among the four tests.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA