Pregled bibliografske jedinice broj: 312481
Analysis of one million base pairs of Neanderthal DNA
Analysis of one million base pairs of Neanderthal DNA // Nature, 444 (2006), 330-336 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 312481 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Analysis of one million base pairs of Neanderthal DNA
Autori
Green, Richard E. ; Krause, Johannes ; Ptak, Susan E. ; Briggs, Adrian W. ; Ronan, Michael T. ; Simons, Jan F. ; Du, Lei ; Egholm, Michael ; Rothberg, Jonathan M. ; Paunović, Maja ; Paabo, Svante
Izvornik
Nature (0028-0836) 444
(2006);
330-336
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Neanderthal DNA; genome sequence
Sažetak
Neanderthals are the extinct hominid group most closely related to contemporary human, so their genome offers a unique opportunity to identify genetic changes specific to anatomically fully modern humans. We have identified a 38, 000-year-old Neandethal fossil that is exceptionally free of contamination from modern human DNA. Direct high-throughput sequencing of a DNA extract from this fossil has thus far yielded over one million base pairs of hominoid nuclear DNA sequences. Comparison with the human and chimpanzee genomes reveals that modern human and Neanderthal DNA sequences diverged on average about 500, 000 years ago. Existing technology and fossil resources are now sufficient to initiate a Neanderthal genome-sequencing effort.
Izvorni jezik
Engleski
Znanstvena područja
Geologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- MEDLINE
