Naslov
Gene expression during embrionic development in diabetic condition
(Influence of hyperglycemia on gene expression during embrionic development)

Autori
Korolija, Marina ; Popović Hadžija, Marijana ; Hadžija, Mirko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 5th Croatian Congress of Pharmacology and 2nd Congress of Croatian Physiological Society ; u: Periodicum biologorum. Supplement 109 (2007) (S) / - Zagreb, 2007

Skup
5th Croatian Congress of Pharmacology and 2nd Congress of Croatian Physiological Society

Mjesto i datum
Osijek, Hrvatska, 19.09.2007. - 22.09.2007

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
diabetes; embryo; gene

Sažetak
Diabetic embryopathy is a complication of diabetes in which the embryo of a diabetic mother develops congenital malformations, mostly of the hart and the neural tube. These malformations arise at the beginning of organogenesis during the first 8 weeks of gestation in human embryos, and during the first 7-10 days in mouse and rat embryos. Our intention was to test whether and to what extent hyperglycemia influences the expression of several genes involved in neural embryonic development in NOD (non-obese diabetic) mice. In order to asses if altered gene expression detected in vivo is due to hyperglycemia, we tested in vitro system that mimics early embryonic development (differentiation of mouse embryonic stem cells as embryoid bodies in culture) at different glucose concentrations.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA