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Pregled bibliografske jedinice broj: 311535

Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats

Pal, Robert; Živin, Marko; Milutinovič, Aleksandra; Jernej, Branimir; Glavan, Gordana
Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats // Neuroscience letters. Supplement, 424 (2007), 3; 194-198 doi:10.1016/j.neulet.2007.07.033 (međunarodna recenzija, članak, znanstveni)

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Naslov
Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats

Autori
Pal, Robert ; Živin, Marko ; Milutinovič, Aleksandra ; Jernej, Branimir ; Glavan, Gordana

Izvornik
Neuroscience letters. Supplement (0167-6253) 424 (2007), 3; 194-198

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dopaminergic hypersensitivity ; in situ hybridization ; preprotachykinin ; proenkephalin ; reserpine ; synaptotagmin VII

Sažetak
Synaptotagmin 7 (Syt 7) is a Ca2+ sensor implicated in the regulation of membrane fusion in vesicular transport, but its precise role in neurons is still a matter of controversy. Dopaminergic drugs have been shown to modulate its expression in the striatum. Here we investigate whether dopamine receptor agonist-up-regulation of Syt 7 mRNA is specifically involved in the pathophysiological adaptations of hypersensitive striatum by analyzing other dopaminergic neurons containing brain regions. We treated rats with systemic reserpine injections that rapidly depletes dopamine throughout the brain, but leaves dopaminergic neurons spared from destruction. We analyzed the effects of apomorphine, a D1 and D2 receptor agonist on Syt 7 mRNA expression in caudate putamen, nucleus accumbens, cingulate cortex, substantia nigra compacta, ventral tegmental area and hippocampus. The treatment with reserpine resulted in akinesia, catalepsy and rigidity and up-regulation of proenkephalin and down-regulation of preprotachykinin mRNA in caudate putamen, indicating a severe depletion. By acute treatment with apomorphine proenkephalin mRNA was down-regulated and preprotachykinin mRNA up-regulated in the caudate putamen of reserpinized rats. Apomorphine increased Syt 7 mRNA levels only in striatum (caudate putamen and nucleus accumbens) of reserpinized rats, while in other brain regions it did not have such effect. The reserpinization and/or apomorphine treatment had no effect on Syt 1 mRNA expression in caudate putamen. It may be concluded, that in the striatum depleted of biogene amines, such as occurs after reserpine treatment, the up-regulation of Syt 7 could play a specific role as part of hypersensitive response to dopaminergic agonists.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Štefulj, Jasminka, MZOS ) ( CroRIS)
MZOS-098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Čičin-Šain, Lipa, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Branimir Jernej (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi

Citiraj ovu publikaciju:

Pal, Robert; Živin, Marko; Milutinovič, Aleksandra; Jernej, Branimir; Glavan, Gordana
Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats // Neuroscience letters. Supplement, 424 (2007), 3; 194-198 doi:10.1016/j.neulet.2007.07.033 (međunarodna recenzija, članak, znanstveni)
Pal, R., Živin, M., Milutinovič, A., Jernej, B. & Glavan, G. (2007) Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats. Neuroscience letters. Supplement, 424 (3), 194-198 doi:10.1016/j.neulet.2007.07.033.
@article{article, author = {Pal, Robert and \v{Z}ivin, Marko and Milutinovi\v{c}, Aleksandra and Jernej, Branimir and Glavan, Gordana}, year = {2007}, pages = {194-198}, DOI = {10.1016/j.neulet.2007.07.033}, keywords = {dopaminergic hypersensitivity, in situ hybridization, preprotachykinin, proenkephalin, reserpine, synaptotagmin VII}, journal = {Neuroscience letters. Supplement}, doi = {10.1016/j.neulet.2007.07.033}, volume = {424}, number = {3}, issn = {0167-6253}, title = {Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats}, keyword = {dopaminergic hypersensitivity, in situ hybridization, preprotachykinin, proenkephalin, reserpine, synaptotagmin VII} }
@article{article, author = {Pal, Robert and \v{Z}ivin, Marko and Milutinovi\v{c}, Aleksandra and Jernej, Branimir and Glavan, Gordana}, year = {2007}, pages = {194-198}, DOI = {10.1016/j.neulet.2007.07.033}, keywords = {dopaminergic hypersensitivity, in situ hybridization, preprotachykinin, proenkephalin, reserpine, synaptotagmin VII}, journal = {Neuroscience letters. Supplement}, doi = {10.1016/j.neulet.2007.07.033}, volume = {424}, number = {3}, issn = {0167-6253}, title = {Effect of apomorphine on striatal synaptotagmin 7 mRNA levels in reserpinized rats}, keyword = {dopaminergic hypersensitivity, in situ hybridization, preprotachykinin, proenkephalin, reserpine, synaptotagmin VII} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI

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