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Pregled bibliografske jedinice broj: 310585

Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain

Gruić-Sovulj, Ita; Rokov-Plavec, Jasmina; Weygand- Đurašević, Ivana
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain // FEBS letters, 581 (2007), 26; 5110-5114 doi:10.1016/j.febslet.2007.09.058 (međunarodna recenzija, članak, znanstveni)

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Naslov
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain

Autori
Gruić-Sovulj, Ita ; Rokov-Plavec, Jasmina ; Weygand- Đurašević, Ivana

Izvornik
FEBS letters (0014-5793) 581 (2007), 26; 5110-5114

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pre-transfer editing ; tRNA-independent pre-transfer editing ; kinetic proofreading ; aminoacyl-adenylate hydrolysis ; seryl-tRNA synthetase

Sažetak
Aminoacyl-tRNA synthetases, a group of enzymes catalyzing aminoacyl-tRNA formation, may possess inherent editing activity to clear mistakes arising through the selection of non-cognate amino acid. It is generally assumed that both editing substrates, non-cognate aminoacyl-adenylate and misacylated tRNA, are hydrolyzed at the same editing domain, distant from the active site. Here, we present the first example of an aminoacyl-tRNA synthetase (seryl-tRNA synthetase) that naturally lacks an editing domain, but possesses a hydrolytic activity toward non-cognate aminoacyl-adenylates. Our data reveal that tRNA- independent pre-transfer editing may proceedwithin the enzyme active site without shuttling the non- cognate aminoacyl-adenylate intermediate to the remote editing site.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA

Projekti:
MZOS-119-0982913-1358 - Strukturna raznolikost seril-tRNA sintetaza i točnost biosinteze proteina (Rokov Plavec, Jasmina; Weygand Đurašević, Ivana, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Jasmina Rokov Plavec (autor)

Avatar Url Ita Gruić-Sovulj (autor)

Avatar Url Ivana Weygand Đurašević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com febs.onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Gruić-Sovulj, Ita; Rokov-Plavec, Jasmina; Weygand- Đurašević, Ivana
Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain // FEBS letters, 581 (2007), 26; 5110-5114 doi:10.1016/j.febslet.2007.09.058 (međunarodna recenzija, članak, znanstveni)
Gruić-Sovulj, I., Rokov-Plavec, J. & Weygand- Đurašević, I. (2007) Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain. FEBS letters, 581 (26), 5110-5114 doi:10.1016/j.febslet.2007.09.058.
@article{article, author = {Grui\'{c}-Sovulj, Ita and Rokov-Plavec, Jasmina and Weygand- \DJura\v{s}evi\'{c}, Ivana}, year = {2007}, pages = {5110-5114}, DOI = {10.1016/j.febslet.2007.09.058}, keywords = {pre-transfer editing, tRNA-independent pre-transfer editing, kinetic proofreading, aminoacyl-adenylate hydrolysis, seryl-tRNA synthetase}, journal = {FEBS letters}, doi = {10.1016/j.febslet.2007.09.058}, volume = {581}, number = {26}, issn = {0014-5793}, title = {Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain}, keyword = {pre-transfer editing, tRNA-independent pre-transfer editing, kinetic proofreading, aminoacyl-adenylate hydrolysis, seryl-tRNA synthetase} }
@article{article, author = {Grui\'{c}-Sovulj, Ita and Rokov-Plavec, Jasmina and Weygand- \DJura\v{s}evi\'{c}, Ivana}, year = {2007}, pages = {5110-5114}, DOI = {10.1016/j.febslet.2007.09.058}, keywords = {pre-transfer editing, tRNA-independent pre-transfer editing, kinetic proofreading, aminoacyl-adenylate hydrolysis, seryl-tRNA synthetase}, journal = {FEBS letters}, doi = {10.1016/j.febslet.2007.09.058}, volume = {581}, number = {26}, issn = {0014-5793}, title = {Hydrolysis of non-cognate aminoacyl-adenylates by a class II aminoacyl-tRNA synthetase lacking an editing domain}, keyword = {pre-transfer editing, tRNA-independent pre-transfer editing, kinetic proofreading, aminoacyl-adenylate hydrolysis, seryl-tRNA synthetase} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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