Naslov
Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6

Autori
Martinez de la Torre, Y. ; Buracchi, C. ; Borroni, E. M. ; Dupor, J. ; Bonecchi, R. ; Nebuloni, M. ; Pasqualini, F. ; Doni, A. ; Lauri, E. ; Agostinis, C. ; Bulla, R. ; Cook, D. N. ; Haribabu, B. ; Meroni, P. ; Rukavina, Daniel ; Vago, L. ; Tedesco, F. ; Vecchi, A. ; Lira, S. A. ; Locati, M. ; Mantovani, A.

Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 104 (2007), 7; 2319-2324

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
trophoblast; leukocyte; placenta; decoy receptor D6

Sažetak
Fetal loss in animals and humans is frequently associated with inflammatory conditions. D6 is a promiscuous chemokine receptor with decoy function, expressed in lymphatic endothelium, that recognizes and targets to degradation most inflammatory CC chemokines. Here, we report that D6 is expressed in placenta on invading extravillous trophoblasts and on the apical side of syncytiotrophoblast cells, at the very interface between maternal blood and fetus. Exposure of D6-/- pregnant mice to LPS or antiphospholipid autoantibodies results in higher levels of inflammatory CC chemokines and increased leukocyte infiltrate in placenta, causing an increased rate of fetal loss, which is prevented by blocking inflammatory chemokines. Thus, the promiscuous decoy receptor for inflammatory CC chemokines D6 plays a nonredundant role in the protection against fetal loss caused by systemic inflammation and antiphospholipid antibodies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA