Naslov
Hyperserotonemia in adults with autistic disorder

Autori
Hranilović, Dubravka ; Bujas-Petković, Zorana ; Vragović, Renata ; Vuk, Tomislav ; Hock, Karlo ; Jernej, Branimir

Izvornik
Journal of Autism and Developmental Disorders (0162-3257) 37 (2007), 10; 1934-1940

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
autism; hyperserotonemia; platelet serotonin level; speech development; verbal communication

Sažetak
Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 &plusmn ; ; ; ; 37.4 ng/lL) was significantly higher than the control sample (59.2 &plusmn ; ; ; ; 16.2 ng/lL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Socijalne djelatnosti

POVEZANOST RADA