Naslov
Inhibition of IL-1 activity induced with allogenic transfusion of UV-irradiated blood
(Inhibition of IL-1 activity induced with allogenic transfusion of UV- Irradiated blood)

Autori
Horvat, Branka ; Poljak-Blaži, Marija ; Hadžija, Mirko

Izvornik
Immunology (0019-2805) 73 (1991), 1; 120-122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
IL-1 ; IL-2 ; UV light ; mice

Sažetak
Treatment with UV-irradiated donor-specific blood transfusion is known to induce specific unresponsiveness in recipient animals and prolong allograft survival. Mixed lymphocyte response in transfused mice was decreased towards spleen cells of the blood donor strain, but was not altered to third-party cells. Sera from treated mice showed significantly lower interleukin-1 (IL-1) activity, which was increased with higher dilutions of sera, indicating the presence of IL-1 inhibitor. Furthermore, sera decreased rIL-1-induced cell proliferation in dose-dependent manner, while the response to rIL-2 neither depended on the concentration of sera, nor differed between non-treated controls and treated mice. These results indicate that UV-irradiated allogeneic blood transfusion could induce an inhibitor, specifically directed to IL-1 activity, which may be involved in the generation of immunological unresponsiveness in treated animals.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA