Naslov
High-Risk Human Papillomavirus (HPV) among Croatian Women

Autori
Milutin Gašperov, Nina ; Sabol, Ivan ; Halec, Gordana ; Matovina, Mihaela ; Grce, Magdalena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme and Abtract Book of the ICGEB DNA Tumor Virus Meeting / Banks, Lawrence - Trst : International Centre for Genetic Engineering and Biotechnology, 2007

Skup
ICGEB (International Centre for Genetic Engineering and Biotechnology) DNA Tumor Virus Meeting

Mjesto i datum
Trst, Italija, 17.07.2007. - 22.07.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Human papillomaviruses (HPV); prevalence; Croatia

Sažetak
The infection with human papillomavirus (HPV) is the central cause of cervical cancer. There are at least 15 high-risk (HR) HPV types that are significantly associated with progression of cervical intraepithelial neoplasia to cervical cancer. Since previous studies showed that the prevalence of HPV in cervical cancers varies among different geographic regions, we wanted to investigate the prevalence of HPV types in Croatia, especially low abundant HR HPV types. By means of consensus primers directed polymerase chain reaction (PCR), we analysed cervical DNA samples of 2, 136 Croatian women, mostly with abnormal cervical smears, in order to detect the presence of HPV. Type-specific primers were then used to determine low-risk HPV types 6/11 and HR HPV types 16, 18, 31, 33, 45, 52 and 58. Out of 2, 136 specimens, 1, 255 (58.8%) were positive for HPV. The most prevalent type was HPV 16 with the prevalence of 15.9%, followed in decreasing order by HPV types 31, 6/11, 33, 18, 52, 45 and 58 with 8.7%, 7.1%, 4.5%, 3.8%, 2.3%, 1.2% and 1.1%, respectively. Our results indicate that prevalence of HR HPV types in Croatia is similar to other European countries.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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