Naslov
Inter-alpha Inhibitor Protein (IaIp) in Term and Preterm Infants at Birth

Autori
K. Singh, E. Siryaporn, K. Bendelja, M. Ručević, Y.P. Lim, J.F. Padbury.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
17th Annual Meeting The Eastern Society for Pediatric Research

Mjesto i datum
Old Greenwich (CT), Sjedinjene Američke Države, 04.03.2005. - 06.03.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Inter-alpha Inhibitor Protein; proteases; Sepsis; Infants

Sažetak
BACKGROUND: IaIp are group of serine proteases inhibitors. They are important in vivo modulators of endogenous proteases including trypsin, human leukocyte elastase, plasmin and cathepsin G. Release of endogenous proteases plays an important role in inflammation, sepsis, wound healing and metastasis. They are produced by the liver and present in adult plasma in the range of 600-1200 mg/liter. A significant decrease of plasma IaIp levels occurs in sepsis. Our previous study has shown that IaIp are produced, independently, by the term as well as preterm newborn infants. OBJECTIVE: The aim of this study is to establish the normal levels of IaIp in term and preterm infants at birth and to evaluate the effect of gender. DESIGN/METHODS: On day of life 0, term and preterm infants, who had a blood sample taken in an EDTA container for any reason, decided by the admitting physician, were included in the study. Those infants with positive blood culture, chromosomal anomalies and significant congenital abnormalities were excluded. Residual blood samples were collected and plasma was extracted and frozen for later analysis. To measure plasma IaIp levels, a competitive ELISA was performed using MAb 69.31 antibody. RESULTS: Plasma was analyzed from 294 infants. Their gestational age ranged from 22 weeks to 41 weeks. The mean IaIp level was 315 mg/liter with a 2 SD range of 237-393 mg/liter. There was no significant difference across the gestational age or gender. CONCLUSIONS: IaIp is present in term and preterm infants’ plasma at the levels of 237-393 mg/liter and there is no significant difference in its level at various gestations and gender.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA