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Pregled bibliografske jedinice broj: 308909

Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines

Martin-Kleiner, Irena; Bombek, Sergeja; Košmrlj, Janez; Čupić, Barbara; Čimbora-Zovko, Tamara; Jakopec, Sanjica; Polanc, Slovenko; Osmak, Maja; Gabrilovac, Jelka
Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines // Toxicology in Vitro, 21 (2007), 8; 1453-1459 doi:10.1016/j.tiv.2007.06.005 (međunarodna recenzija, članak, znanstveni)

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Naslov
Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines

Autori
Martin-Kleiner, Irena ; Bombek, Sergeja ; Košmrlj, Janez ; Čupić, Barbara ; Čimbora-Zovko, Tamara ; Jakopec, Sanjica ; Polanc, Slovenko ; Osmak, Maja ; Gabrilovac, Jelka

Izvornik
Toxicology in Vitro (0887-2333) 21 (2007), 8; 1453-1459

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diazenes ; cytotoxicity ; leukemic cell lines

Sažetak
In this study, the cytotoxicity of 16 diazenes towards four human leukemic cell lines was tested. Regarding their structure these 16 diazenes belong to three subclasses: diazenecarboxamides (11 compounds), diazenedicarboxamides (4 compounds) and alkyl aminocarbonyldiazenecarboxylate (1 compound). The leukemic cell lines used in this study were NALM-1, JURKAT, HL-60 and K-562. Fifteen out of 16 tested diazenes were cytotoxic towards the leukemic cell lines: 11 with high efficacy (IC50 < 50 μ M) at least towards two to three leukemic cell lines, and 4 with medium efficacy (IC50 > 50 μ M). Ten out of these 11 diazenes have a common structure and belong to the subclass of diazenecarboxamides. Five diazenes (SB-681, LK-34, UP-39, JK-1197, UP-11) were highly cytotoxic (IC50 values 3.3– 38.9 μ M) towards all four leukemic cell lines. The selectivity of the cytotoxicity towards leukemic cells was tested by using resting and Con-A-stimulated peripheral blood mononuclear cells (PBMC) isolated from healthy donors and towards normal mouse fibroblast cell line, 3T3. The diazenes cytotoxic towards leukemic cells, did not affect the viability of the resting PBMC suggesting selectivity of their action. Moreover, eight diazenes did not affect the normal dividing cells (Con-A-stimulated PBMC and fibroblasts). Thus, we present eight diazenes which are selectively cytotoxic towards leukemic cells, not affecting normal cells even when activated to proliferation. These compounds may represent new potential agents for the treatment of leukemia patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2520 - Uloga membranskih peptidaza na tumorskim i normalnim stanicama (Gabrilovac, Jelka, MZOS ) ( CroRIS)
098-0982913-2748 - Stanični odgovor na citotoksične spojeve i razvoj otpornosti (Osmak, Maja, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Jelka Gabrilovac (autor)

Avatar Url Maja Osmak (autor)

Avatar Url Irena Martin-Kleiner (autor)

Avatar Url Barbara Čupić (autor)

Avatar Url Tamara Čimbora Zovko (autor)

Avatar Url Sanjica Rak (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Martin-Kleiner, Irena; Bombek, Sergeja; Košmrlj, Janez; Čupić, Barbara; Čimbora-Zovko, Tamara; Jakopec, Sanjica; Polanc, Slovenko; Osmak, Maja; Gabrilovac, Jelka
Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines // Toxicology in Vitro, 21 (2007), 8; 1453-1459 doi:10.1016/j.tiv.2007.06.005 (međunarodna recenzija, članak, znanstveni)
Martin-Kleiner, I., Bombek, S., Košmrlj, J., Čupić, B., Čimbora-Zovko, T., Jakopec, S., Polanc, S., Osmak, M. & Gabrilovac, J. (2007) Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines. Toxicology in Vitro, 21 (8), 1453-1459 doi:10.1016/j.tiv.2007.06.005.
@article{article, author = {Martin-Kleiner, Irena and Bombek, Sergeja and Ko\v{s}mrlj, Janez and \v{C}upi\'{c}, Barbara and \v{C}imbora-Zovko, Tamara and Jakopec, Sanjica and Polanc, Slovenko and Osmak, Maja and Gabrilovac, Jelka}, year = {2007}, pages = {1453-1459}, DOI = {10.1016/j.tiv.2007.06.005}, keywords = {diazenes, cytotoxicity, leukemic cell lines}, journal = {Toxicology in Vitro}, doi = {10.1016/j.tiv.2007.06.005}, volume = {21}, number = {8}, issn = {0887-2333}, title = {Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines}, keyword = {diazenes, cytotoxicity, leukemic cell lines} }
@article{article, author = {Martin-Kleiner, Irena and Bombek, Sergeja and Ko\v{s}mrlj, Janez and \v{C}upi\'{c}, Barbara and \v{C}imbora-Zovko, Tamara and Jakopec, Sanjica and Polanc, Slovenko and Osmak, Maja and Gabrilovac, Jelka}, year = {2007}, pages = {1453-1459}, DOI = {10.1016/j.tiv.2007.06.005}, keywords = {diazenes, cytotoxicity, leukemic cell lines}, journal = {Toxicology in Vitro}, doi = {10.1016/j.tiv.2007.06.005}, volume = {21}, number = {8}, issn = {0887-2333}, title = {Selective cytotoxicity of diazenecarboxamides towards human leukemic cell lines}, keyword = {diazenes, cytotoxicity, leukemic cell lines} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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