Naslov
Structure and Reactivity of the Several Biologically Active Oxime Derivatives of Pyridinium Chloride

Autori
Picek, Igor ; Foretić, Blaženka ; Lovrić, Jasna ; Burger, Nicoletta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
12th European Conference on the Spectroscopy of Biological Molecules : Book of Abstracts / Ghomi, Mahmoud ; Hernandez, Belen - Bobigny, 2007, 302-302

Skup
12th European Conference on the Spectroscopy of Biological Molecules

Mjesto i datum
Pariz, Francuska, 01.09.2007. - 06.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Oximes; Pentacyanoferrate(II); Structure and Reactivity

Sažetak
Oximes, members of the family of aralkyl derivatives of pyridinium chloride, are known as reversible inhibitors of human blood cholinesterase. Consequently, they are efficient protectors of this enzyme upon phosphorylation by organophosphorous poisons such as pesticides and warfare agents [1]. Their biological functions and metabolizing mechanisms in living systems are usually related to their structure and chelating ability. The reinvestigation of previously reported [2, 3] coordination ability of the selected aralkyl derivatives of pyridinium cation (Table 1) to the pentacyanoferrate(II) moiety have shown considerable differences concerning their stability and reactivity in aqueous solutions. In order to clarify the differences between those otherwise similar compounds a detailed structural characterisation by means of UV-Vis, NMR (1H and13C), FT-IR and Raman is preformed. Table 1. The examined oxime derivatives of pyridinium chloride Name Cation Abbrev. 1-Benzylpyridinium-4-aldoxime chloride BPA-4 1-Phenacylpyridinium-4-aldoxime chloride FEPA-4 1-Benzoylethylpyridinium-4-aldoxime chloride BEPA-4 The results are correlated with their reactivity toward the aquapentacyanoferrate(II) ion, as a model of biologically important macromolecules with labile sixth coordination site, and the stability of produced complexes. References [1]A. L. Vrdoljak, J. Lovrić, B. Radić, V. Žlender, Basic Clin. Pharmacol. Toxicol. 99 (2006), 17-21. [2]N. Burger, V. Hankonyi, Z. Smerić, Z.Phys. Chemie, Leipzg 271 (1990), 787-791. [3]B. Foretić, J. Lovrić, N. Burger, J. Coord. Chem. 59 (2006), 1537-1539.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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