Pregled bibliografske jedinice broj: 308376
TNF-alpha promoter SNP -1031 C is associated with susceptibility for gastroenteropancreatic neuroendocrine tumors (GEP-NETS)
TNF-alpha promoter SNP -1031 C is associated with susceptibility for gastroenteropancreatic neuroendocrine tumors (GEP-NETS) // Joint ICMS-AACR International Conference on Tumor Microenvironment / Witz, Isaac (ur.).
Firenza : München: The International Cancer Microenvironment Society, 2007. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 308376 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
TNF-alpha promoter SNP -1031 C is associated with susceptibility for gastroenteropancreatic neuroendocrine tumors (GEP-NETS)
Autori
Berković, Maja ; Čačev, Tamara ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Joint ICMS-AACR International Conference on Tumor Microenvironment
/ Witz, Isaac - Firenza : München : The International Cancer Microenvironment Society, 2007
Skup
Joint ICMS-AACR International Conference on Tumor Microenvironment
Mjesto i datum
Firenca, Italija, 06.03.2007. - 10.03.2007
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
TNF-alpha; GEP-NETs
Sažetak
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare, heterogeneous group of tumors secreting biogenic amines, hormones and growth factors, among which tumor necrosis factor alpha (TNF-α ). As the expression of TNF-α is mostly regulated at the transcriptional level, promoter polymorphisms of its gene, leading to aberrant TNF-α production and possibly cancer susceptibility have intensively been studied. We have analyzed for the first time the potential association between -238, -308, -857 and -1031 TNF-α promoter polymorphisms and GEP-NETs. The study included 65 individuals diagnosed with GEP-NET and 154 healthy age and sex matched controls. Most of the patients had solitary GEP-NETs, while six had neuroendocrine tumors as a part of multiple endocrine neoplasia type 1 (MEN-1) and one as a part of neurofibromatosis type 1 (NF-1). The C allele at the -1031 position was more frequent in GEP-NET patients (p<0.0005) suggesting its putative role in GEP-NET development. The significant difference between forgut and midgut GEP-NET patients was observed in the -308 high expression genotypes and -308A allele (high expression) which tend to occur more frequently in the forgut GEP-NETs (p=0.0392 and p=0.0350 respectively). No differences were observed in the frequencies of -238A or -857T alleles between GEP-NET patients and healthy controls. The results suggest the putative role of TNF-α -1031 polymorphism in the development of GEP-NET.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"
