Naslov
Detection of minimal residual disease in acute promyelocytic leukemia by polymerase chain reaction assay for PML/RARalpha (retinoic acid receptor-alpha) fusion transcript.

Autori
Nemet, Damir ; Grahovac, Blaženka ; Labar, Boris ; Mrsić, Mirando ; Bogdanić, Vinko ; Hitrec, Vlasta ; Zaher, Dunja ; Zadro, Renata ; Boban, Dubravka

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Molecular Oncology Today / Osmak, Maja ; Škrk, Janez - Zagreb : Croatian Ligue Against Cancer, 1996, 149-153

Skup
Molecular Oncology Today

Mjesto i datum
Zagreb, Hrvatska, 19.12.1995

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acute promyelocytic leukemia; PML/RAR alpha; PCR assay; all-trans retinoic acid

Sažetak
Seven patients with acute promyelocytic leukemia (APL)treated with all-trans retinoic acid (ATRA) for remission (CR) induction and with chemotherapy (CT) for consolidation of CR underwent residual disease monitoring through reverse transcription polymerase chain reaction (PCR) for PML/retinoic acid receptor alpha (PML/RAR alpha) fusion transcript. In six patients PCR was positive immediately after ATRA induced CR and/or after the first CT course.Two patients became PCR negative following repeated courses of CT and they are in remission 7 and 14 months, respectively. Four other patients relapsed. This pilot study indicates that PCR for PML/RAR alpha is very sensitive assay for detection of residual disease in APL.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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