Naslov
Cerebral vascular reactivity to hypercapnia is unchanged in apnea divers

Autori
Ivančev, Vladimir ; Valić, Zoran ; Palada, Ivan ; Obad, Ante ; Baković, Darija ; Dietz, Niki M. ; Joyner, Michael J. ; Dujić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Experimental Biology 2007 : Abstracts / - , 2007, A1360-A1360

Skup
Experimental Biology 2007

Mjesto i datum
Sjedinjene Američke Države, 28.04.2007. - 02.05.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hypercapnia; obstructive sleep apnea; cerebrovascular reactivity; diving

Sažetak
Hypercapnic cerebrovascular reactivity is decreased in obstructive sleep apnea and congestive heart disease patients. Ventilatory response to hypercapnia and/or hypoxia is blunted in apnea divers, whereas cerebrovascular reactivity to hypercapnia is presently unknown. We hypothesized that cerebrovascular reactivity to hypercapnia is increased in elite apnea divers, compared to control subjects, as a part of the O2 conserving mechanism to maintain adequate brain O2 supply. In the present study we determined cerebrovascular reactivity by measuring change in middle cerebral artery velocity per mmHg change in PETCO2 in response to two hyperoxic hypercapnia rebreathing maneuvers in seven elite apnea divers and seven control subjects. Ventilatory response to hypercapnia was blunted in divers compared to controls. Hypercapnia-induced ventilation increase was significantly lower in divers due to lower respiratory frequency. Cerebrovascular reactivity was unchanged in both groups (3.7± 1.4 vs 3.4± 1.3 %/mmHg PETCO2 in divers and controls) and the same was found for cerebral vascular resistance and a time for middle cerebral artery velocity recovery to baseline value. Results indicate that the regulation of the cerebral circulation in response to hypercapnia shows no difference between divers and controls serving as protective mechanism against chronic intermittent cerebral hypoxia/hypercapnia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Zbornik tiskan u časopisu The FASEB journal 21(2007) u jednom od 3 sveščića izašlih u travnju ; ISSN 0892-6638.

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