Naslov
Interpretation of natural fluctuations of metallothioneins and metal levels in the aquatic organisms

Autori
Raspor, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Tumor Biology, The Journal of the International Society for Oncodevelopmental Biology and Medicine (ISOBM) / Stigbrand, T. - Basel : Karger Publishers, 2007, 42-42

ISBN
ISSN 1010-4283

Skup
The 35th Meeting of the International Society for Oncodevelopmental Biology and Medicine, ISOBM2007

Mjesto i datum
Prag, Češka Republika, 15.09.2007. - 19.09.2007

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Biomarker of metal exposure; metallothionein; auqatic organisms

Sažetak
Metallothionein (MT) is established as a biomarker of metal exposure of aquatic organisms. In different tissue types, like gills, liver, kidney, intestine, of the aquatic organisms the levels of MT are related to the cytosolic metal concentrations (Zn, Cu, Cd) that induce the MT synthesis. Exposure of the aquatic organisms (shellfish and fish) under the controlled conditions clearly indicates de nuovo MT synthesis, but those experiments are performed at elevated metal levels that are usually not relevant for environmental conditions. In the field studies, fluctuations of different magnitude are observed for MT and cytosolic metal concentrations. They reflect individual response of the organism to different abiotic and biotic conditions, e.g. food availability, age, reproductive cycle etc. Therefore, within the overall MT concentration at the cellular level, the contribution of natural (biotic and abiotic) parameters to the basal level of MT and cytosolic metals, has to be defined before interpreting the results as being affected by metal pollution. Field studies conducted on indigenous fish and shellfish will be illustrated and discussed with respect to the limitations of using MT as the biomarker of metal pollution, in the indigenous aquatic organisms. References: V. Filipović Marijić and B. Raspor (2007) Metal exposure assessment in native fish, Mullus barbatus L., from the Eastern Adriatic Sea, Toxicology Letters: 168(292-301). B. Raspor, Z. Dragun, M. Erk, D. Ivanković and J. Pavičić (2004) Is the digestive gland of Mytilus galloprovincialis a tissue of choice for estimating cadmium exposure by means of metallothioneins?, Science of the Total Environment: 333(99-108).

Izvorni jezik
Engleski

Znanstvena područja
Geologija

POVEZANOST RADA