Histopathology Changes of Gut Mucosa during Anesthesia and Abdominal Surgical Procedures

Dmitrović, Branko; Gulam, Danijela; Kovačić, Damir; Kovačić, Borna; Zibar, Lada

Pregled bibliografske jedinice broj: 306250

Histopathology Changes of Gut Mucosa during Anesthesia and Abdominal Surgical Procedures

Dmitrović, Branko; Gulam, Danijela; Kovačić, Damir; Kovačić, Borna; Zibar, Lada

Histopathology Changes of Gut Mucosa during Anesthesia and Abdominal Surgical Procedures // Virchows Archiv / Bilgic, Bilge ; Blokx, Willeke ; Bruder, Elisabeth ; et al. (ur.).
Heidelberg: Springer, 2007. (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 306250 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Histopathology Changes of Gut Mucosa during Anesthesia and Abdominal Surgical Procedures

Autori
Dmitrović, Branko ; Gulam, Danijela ; Kovačić, Damir ; Kovačić, Borna ; Zibar, Lada

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Virchows Archiv / Bilgic, Bilge ; Blokx, Willeke ; Bruder, Elisabeth ; et al. - Heidelberg : Springer, 2007

Skup
21st European Congress of Pathology

Mjesto i datum
Istanbul, Turska, 08.09.2007. - 13.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
: intestinal mucosa; anesthesia; abdominal surgery; anoxia

Sažetak
AIM: A perfusion and integrity of small bowel mucosa were examined during anesthesia and surgery on open abdomen in 60 patients in various length treatments. MATERIAL AND METHODS: Patients (44 man, 16 woman) age range was 21 to 80 years (mean age 58 years). During the surgery, two samples of the intestinal mucosa were removed: T0 at the beginning of the procedure, and TN at the end (N = treatment duration in hours – 2 to 7 hours). All the biopsies were examined and classified according to the observed mucosal injury into 4 grades (Knichwitz: Crit Care Med 1998 ; 26:1550-7): grade 0 – no injury, grade 1 – isolated hemorrhage in lamina propria, grade 2 – lifting of the villus epithelium and isolated hemorrhage, grade 3 – damaged villi and hemorrhage, grade 4 – damaged villi and ulcerations with necrosis. RESULTS: The changes of intestinal mucosa were found in 31 patients (51.7%): in 19 patients (31.7%) grade 1 changes were recorded, in 10 patients (16.7%) grade 2, and in 2 patients (3.3%) grade 3. Grade 4 lesions were not recorded. CONCLUSIONS: During the anesthesia and surgery on open abdomen, the length of the procedure influences the grade of the intestinal mucosa injury. Aggravation of the patohistological changes in intestinal mucosa correlates with high lactate blood level (p<0.001), proving that the cause of these changes is connected with tissue hypoxia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
219-2192382-2009 - Procjena učinaka višesatne abdominalne kirurgije na perfuziju tankog crijeva (Dmitrović, Branko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Branko Dmitrović (autor)