Pregled bibliografske jedinice broj: 306142
Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic vs calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability on human blood lymphocytes
Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic vs calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability on human blood lymphocytes // Nucleosides, nucleotides & nucleic acids, 26 (2007), 8/9; 989-993 doi:10.1080/15257770701508513 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 306142 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic vs calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability on human blood lymphocytes
Autori
Glavaš-Obrovac, Ljubica ; Suver, Mirjana ; Hikishima, Sadao ; Yokomatsu, Tsutomu ; Bzowska, Agnieszka
Izvornik
Nucleosides, nucleotides & nucleic acids (1525-7770) 26
(2007), 8/9;
989-993
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
purine nucleosid phosphorylase; difluoromethylenephosphonic acid; Hashimoto's thyroiditis
Sažetak
Several cyclic and acyclic 6-keto purine nucleotides with difluoromethylenephosphonic acid as phosphate mimic are proved to be potent inhibitors of mammalian purine nucleoside phosphorylase (PNP). Antiproliferative activity of these analogues on the growth of human blood lymphocytes was tested by MTT assay. Compared to inhibitory effects on the growth of human blood T-lymphocytes isolated from healthy donors, all analogues significantly slow down proliferation of lymphocytes isolated from patients with autoimmune thyroid disease – Hashimoto’ s thyroiditis.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
0127111
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)
Ustanove:
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)
- CA Search (Chemical Abstracts)