Naslov
Transdifferentiation of retinal cells: a possible mechanism of lentoidogenesis in human teratomas.

Autori
Bulić-Jakuš, Floriana ; Jurić-Lekić, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / Belicza, Mladen ; Krušlin, Božo - Zagreb : Hrvatska liga za borbu protiv raka, 1996, 28-28

Skup
I. Hrvatski kongres patologa i sudskih medicinara

Mjesto i datum
1996., 26.09.1996. - 28.09.1996

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
transdifferentiation; retinal cells; lentiodogenesis; human teratomas

Sažetak
Cells of the ocular lens differentiate from the surface ectoderm. However, in rat experimental teratomas originating from gastrulating embryos transferred to ectopic sites (under the kidney capsule or in vitro) they probably develop from neural retina cells by the process of transdifferentiation (metaplasia). Direct evidence of this process in humans was obtained in vitro. Only in one case of female newborn sacrococcygeal teratoma, cells of the ocular lens were found. The presence of masses of primitive neural retina cells surrounding lentoids, as well as the absence of epidermal structures in their vicinity, led us to the conclusion that in this case lentoids probably also developed by the process of transdifferentiation of neural retina cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA