Naslov
Association between cerebral palsy, infection, inflammation and cytokines: mini review

Autori
Kapitanović Vidak, Helena ; Kapitanović, Sanja

Izvornik
Periodicum biologorum (0031-5362) 108 (2006), 5; 563-566

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cerebral palsy ; infection ; inflammation ; cytokines

Sažetak
Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. The cause and pathogenesis of CP is multifactorial and continues to be poorly understood, however, prematurity is considered to be the leading risk factor for the development of CP. During the last decade, intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS (Fetal Inflammatory Response Syndrome). Activation of the cytokine network and elevated levels of proinflammatory cytokines can cause white matter brain damage and preterm delivery, as well as the future development of CP. This white matter insult is identified by brain ultrasound examination as periventricular leucomalacia (PVL), which has been associate with subsequent impaired neurological outcomes of variable severity, including CP. Recent data suggest that a relative abundance of pro-inflammatory cytokines may favour neuronal cell death while overexpression of anti-inflammatory cytokines may prevent brain injury. The balance between pro- and anti-inflammatory cytokines in neonatal brain is therefore likely to be critical in determining the initiation, development and consequences of cerebral injury. Individual infants display a spectrum of severity of damage following apparently comparable insults. Such variation may depend of the complicated interaction of the multiple aetiological factors and on the genetic susceptibility of the individual including polymorphisms in pro- and anti-inflammatory cytokine genotypes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA