Naslov
Effectiveness of novel PGM-containing incomplete Seppic adjuvants in rabbits

Autori
Halassy, Beata ; Vdović, Valerija ; Habjanec, Lidija ; Lang Balija, Maja ; Gebauer, Branka ; Sabioncello, Ante ; Šantek, Tomislav ; Tomašić, Jelka

Izvornik
Vaccine (0264-410X) 25 (2007), 17; 3475-3481

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Peptidoglycan monomer; Montanide ISA 206; Montanide ISA 720; Adjuvants

Sažetak
Peptidoglycan monomer (PGM) is adjuvant active molecule in experimental mice, although its adjuvanticity is much lower in comparison to potent adjuvants. The novel adjuvant formulations were developed by incorporation of PGM into Montanide ISA 206 and ISA 720 adjuvants, with the aim to enhance its adjuvanticity by protecting it from the fast degradation and metabolic clearance. Adjuvanticity of the novel adjuvant formulations was tested in rabbits for induction of protein-specific antibodies. Both novel adjuvants ISA206PGM and ISA720PGM were significantly stronger than Montanide adjuvants themselves, and also significantly more potent than Complete Freund Adjuvant. Montanide ISA 720 was shown as much better carrier of PGM, since the novel ISA720PGM adjuvant was significantly stronger adjuvant than the ISA206PGM.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Drvna tehnologija

POVEZANOST RADA