Naslov
Electrode reaction of adriamycin interpreted as an EE mechanism with the stabilization of the intermediate

Autori
Komorsky-Lovrić, Šebojka ; Lovrić, Milivoj

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / Jirži Ludvik - Prag : Czech Academy of Sciences, 2007

Skup
40th Heyrovsky Discussion

Mjesto i datum
Třešť, Češka Republika, 10.06.2007. - 14.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Adriamycin; Doxorubicin; Surface ECE mechanism; Quinone / hydroquinone redox couple; Cyclic voltammetry: Graphite electrode

Sažetak
In the case of the simple EE mechanism, the two-electron electrode reaction occurs through two consecutive steps with a more or less stable intermediate  1 . The homogeneous chemical reaction can be coupled to any step of the EE mechanism  2 . In this communication the electrode reaction of adsorbed adriamycin is interpreted as an EE mechanism with the stabilization of the intermediate. Adriamycin is the commercial name for doxorubicin hydrochloride which consists of naphthacenequinone nucleus linked through a glycosidic bond to an amino sugar, daunosamine (Scheme). Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius  3 . Adriamycin is electroactive substance. The redox centers are quinone and hydroquinone groups, which are marked as 1. and 2. in the Scheme  4 . Also, adriamycin is strongly adsorbed to the surface of mercury, pyrolytic graphite, carbon paste and glassy carbon electrodes  5 . References: (1) Ružić, I. J. Electroanal. Chem. 1974, 52, 331. (2) Lovrić, M. J. Electroanal. Chem. 1983, 144, 45. (3) Arcamone, F. Doxorubicin, Academic Press, New York, 1981, pp. 354. (4) Oliveira-Brett, A.M. ; Vivan, M. ; Fernandes, I.R. ; Piedade, J.A.P. Talanta 2002, 56, 959. (5) Komorsky-Lovrić, Š. Bioelectrochem. 2006, 69, 82.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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