Naslov
Mild cognitive impairment in symptomatic and asymptomatic cerebrovascular disease

Autori
Popović Martinić, Irena ; Šerić, Vesna ; Demarin, Vida

Izvornik
Journal of the Neurological Sciences (0022-510X) 257 (2007), 1-2; 185-193

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
brain-pathology; brain-physiopathology; cerebrovascular disease- diagnostics; dementia

Sažetak
We tried to evaluate and to compare usefulness of two brief cognitive tests in early detection of cognitive decline in subjects with increased cerebrovascular (CV) risk. As CV risk factors are recognised as important in etiology of dementia, we also aimed to determine the possible associations of specific CV risk factors and cognitive results. Patients (PGs) with first-ever stroke or TIA (N = 110) and CV symptoms-free controls (CGs) with CV risk factors present (N = 45) matched for age, gender and education level were tested using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) on admission, at three- and six-month points. In all subjects, detailed CV risk factors profile was assessed. We observed the decrement in cognitive performance during the six-month study period in both groups, more evident if MoCA (p < 0.001) than if MMSE was used (p = 0.022). Six months after first stroke/TIA 83.6% PGs scored below normal range on MoCA. In PGs, positive associations for cognitive decrement and multiple CV risk factors (> 2) were found (p = 0.034 for MMSE ; p = 0.002 for MoCA). In CGs, positive associations were found for cognitive decrement and arterial hypertension with increased IMT values (p < 0.001 for MMSE) and for multiple CV risk factors and arterial hypertension (p = 0.003 for MoCA). The use of MoCA could aid to early recognition of cognitive deficits in persons with increased CV risk. Individuals with multiple CV risk factors seem to have increased risk of cognitive decline.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Volume 257, Issues 1-2, Pages 1-286 (15 June 2007), Vascular Dementia - Proceedings of the Fourth International Congress on Vascular Dementia, Porto, Portugal on October 20-23, 2005, Fourth International Congress on Vascular Dementia Porto, Portugal Edited by Amos D. Korczyn and Natan M. Bornstein

POVEZANOST RADA