Naslov
Interleukin-6 mRNA expression in sporadic colon cancer

Autori
Čačev, Tamara ; Kapitanović, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Inflammation Research 56(3) / Parnham, MJ - Kopenhagen : Birkhäuser, 2007

Skup
8th World congress on inflammation

Mjesto i datum
Kopenhagen, Danska, 15.06.2007. - 21.06.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
IL-6; sporadic colon cancer

Sažetak
Colon cancer is one of the most frequently diagnosed cancers in Western Societies. Interleukin-6 (IL-6) is a potent, pleiotropic, inflammatory cytokine that contributes to a multitude of physiological and pathophysiological processes. IL-6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. A variety of studies have demonstrated that over expression of IL-6 contributes to the pathogenesis of various inflammatory diseases as well as cancer. It has been reported that human colorectal cancer cells display a wide heterogeneity in their potential to express and produce IL-6. Serum levels of IL-6 are elevated in patients with colorectal cancer, however serum levels of IL-6 were found to be independent of IL-6 mRNA expression in tumor tissue. In this study we analyzed IL-6 mRNA expression by real-time PCR in 50 sporadic colon cancer tissue as well as corresponding normal mucous tissue. IL-6 mRNA expression in tumor tissue was lower than in the corresponding normal mucous tissue (p=0, 0074). There was no correlation between IL-6 mRNA expression and tumor grade or stage. Thus we can conclude that IL-6 produced at the tumor site is not involved in sporadic colon cancer progression.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA