Naslov
Cerebrospinal fluid tau proteins in evaluation of patients with suspected dementia

Autori
Boban, Marina ; Grbić, Kristina ; Hof, Patrick ; Hamann, Christine ; Ackl, Nibal ; Mimica, Ninoslav ; Bader, Benedikt ; Danek, Adrian ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
37th Professor Janez Plečnik Memorial Meeting with an International Symposium on Recent Progress in Dementia Research : Abstracts ; u: Clinical Neuropathology 25 (2006) (6) / Weis, J - München : Dustri Verlah, 2006, 306-306

Skup
Professor Janez Plečnik Memorial Meeting with an International Symposium on Recent Progress in Dementia Research (37 ; 2006)

Mjesto i datum
Ljubljana, Slovenija, 07.12.2006. - 08.12.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease; tau protein; cerebrospinal fluid; early diagnosis

Sažetak
Abnormal hyperphosporylation of the microtubule-associated protein tau and its incorporation into neurofibrillary tangles are major hallmarks of the pathogenesis of Alzheimer's disease (AD). The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Using monoclonal antibodies different tau phosphoepitopes can be sensitively detected in CSF. We analyzed CSF of patients with suspected early Alzheimer's disease, patients with suspected other primary cause of dementia and normal controls. Our findings largely confirmed that total tau and phosphorylated tau-181 may be very useful, complementary biological markers for distinguishing AD from other primary causes of dementia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija

POVEZANOST RADA