Pregled bibliografske jedinice broj: 299030
Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy
Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy // Croatica Chemica Acta, 80 (2007), 2; 211-216 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 299030 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Epitope Mapping of Macrolide Antibiotics to Bovine Serum Albumin by Saturation Transfer Difference NMR Spectroscopy
Autori
Novak, Predrag ; Tepeš, Predrag ; Lazić, Vedrana
Izvornik
Croatica Chemica Acta (0011-1643) 80
(2007), 2;
211-216
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
STD NMR spectroscopy; macrolide antibiotics; albumine; epitope mapping
Sažetak
Saturation transfer difference NMR spectroscopy was employed to characterize epitopes of macrolide antibiotics, azithromycin, oleandomycin and telithromycin binding to bovine serum albumine. The structural parts of azithromycin and oleandomycin in intimate contact to bovine serum albumine were found to be similar while those of telithromycin showed similarities but also some differences. Those were mostly due to different structural elements of antibiotics that interact with the protein especially alkyl-heteroaryl side chain in telithromycin and cladinose and desosamine sugars in azithromycin and oleandomycin. The epitope maps as determined in this study can help in better understanding of the overall bioactivity of macrolides.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Novak, Predrag, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
