Naslov
Detection and characterization of measles virus strains in cases of subacute sclerosing panencephalitis in Croatia

Autori
Forčić, Dubravko ; Baričević, Marijana ; Zgorelec, Renata ; Kružić, Vladimira ; Kaić, Bernard ; Marušić Della Marina, Branka ; Cvitanović Šojat, Ljerka ; Tešović, Goran ; Mažuran, Renata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Croatian congress on infectious diseases / Blaha, Jasminka ; Jakopović, Nevenka ; Pavelić, Arijana - Zagreb, 2004, 63-63

Skup
4. HRVATSKI KONGRES O INFEKTIVNIM BOLESTIMA S MEĐUNARODNIM SUDJELOVANJEM

Mjesto i datum
Opatija, Hrvatska, 02.10.2004. - 06.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
SSPE; measles; genotype; mutations

Sažetak
Two cases of subacute sclerosing panencephalitis (SSPE), diagnosed in Croatia in 2002, were investigated. In addition to published sequences of N, M and H genes (Virus Res, 99, 2004), the complete coding regions of P, F and L genes were sequenced following direct RT-PCR of viral RNA extracted from brain tissue. Phylogenetic analysis of the sequences of H and N genes, showed that both strains belonged to genotype D6. The comparison of analyzed sequences of two SSPE causative viruses with each other and with sequence of possible progenitor (measles virus prevailing in Europe at roughly the same time as the primary infection) revealed a number of mutation. The M and F gene of the SSPE viruses showed a premature termination codon in one of the patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA