Naslov
Intra- and intergenotype characterization of D6 measles virus genotype

Autori
Šantak, Maja ; Baričević, Marijana ; Mažuran, Renata ; Forčić Dubravko

Izvornik
Infection, Genetics and Evolution (1567-1348) 7 (2007), 5; 645-650

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
measles virus; genotype D6; mutations; stability; variability

Sažetak
Determination of inter- and intragenotype stability and variability is the basic tools for the molecular epidemiology and evolutionary investigation of measles virus (MV). We made a comparison between complete genome sequences of four MVs (two wt MV strains- WA.USA/17.98 and 97-45881, and two SSPE MV strains- MVs/Zagreb.CRO/47.02/ and MVs/Zagreb.CRO/08.03/), all belonging to genotype D6. Results of analyses clearly confirm that MVgenome continuously changes within the viruses of the same or different genotypes by accumulation of mutations in different parts of the genome. Only a small number of these accumulated mutations induce amino acid substitutions and thus possibly introduce new biological characteristics or a new genotype over a long time period. This study clearly reveals a long untranslated region between M and F genes as the most variable region of the MV genome and detects the presence of unique residues on the level of the entire genome as a new important parameter in the investigation of molecular evolution of MVs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA